Coding

Part:BBa_K2171001:Design

Designed by: Slavil Peykov, Desislava Popova   Group: iGEM16_Bulgaria   (2016-10-14)


RvLEAM - osmotic stress protein from tardigrade


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


The "lacI-lacIq and a tac promoter" subpart was amplified from part BBa_K731520 using primers:

F: tatgaattcgcggccgcttctagagTCACTGCCCGCTTTCCAGTC

R: CTAGTACTTTCCTGTGTGACTC


"RvLEAM CDS + transcription terminators" subpart was ordered as gBlock from IDT


Sequence: 

ATATAATTGAATTCGCGGCCGCTTCTAGATGTTTTTAGCTCGTAATGCTGGCCGTGCAGGCTA
TCGCGGTGTAGTGGCGTATCAGCAAGCCGCTTCTTTCAGCGTGAGTTCCGCAAAAGCTGCCGG
ATCACGCTCGTCTGGGGGGAGTGACGCGGGAGACTATGCCCGCGAGGCCGCGGAGCACGCTAA
GGCAGGATTGAAGGACCTTAAAAACGAGGCGTCTTGGAAAGCTAAAGGAGTTGCGAACCAAGC
CGCCGGTGCTTTTGAGCGTGCTAAAGATACTGTGAAGGAGGGGGTCCACGACATGAAACGCTC
AGGTAGTCGCGTTTTCGAACAAGGACAAGAGGAAGTGGAAGCCGGTGCTCAGCACGCTAAGGC
AGGCTACCAAAGCGCCAAAAATGCGGCACAGGATACGGCTGCTACATTGAAGGACAAGGCGGG
GTCCGCTTGGAACCAGGCCAAACACGTTGTGGAAGACAAGGGTGAGGACGTTGTCGAAGCTGT
TAAAGACACCGCAAGTAAGGTCTGGGGAAAAGCCAAACACGTTGCTGAGGACGTAAAGGAGAA
TGCGCAATCCCCCGGCGGAATCGCTGACAAAGCCTCGGATGTATGGTCCGCAGCTAAGGATAA
AGCTGCGGACGTGCTGAGCGGCGCTAAGCACACGGCCGAGAACTTGGCGCACAAGGCGCAAGC
CGCTATCCACGATGCAACGGCATCTAGCGGGTCCCAGTCACAGTCTCAATCCCAATCACAATA
TCGCCAGGGCCAACAGCAAGGTCGTCAAGATCAACAACAAAGCAAAAGCCAATGGGGACAGAC
CTCACCCCAGTCGCCTGACGGGTTTCGTCCACAAGCTGGTCAAGGTCCCCAGGGCGGGAAAGG
GCCGGGACAGGCCGGAGGCCGTCGTTAATAATTGATTAACATCAAATAAAACGAAAGGCTCAG
TCGAAAGACTGGGCCTTTCGTTTTATCTGTTGTTTGTCGGTGAACGCTCTCTACTAGAGTCAC
ACTGGCTCACCTTCGGGTGGGCCTTTCTGCGTTTATTACTAGTAGCGGCCGCTGCAGTTATAT
AT 


and amplified using primers:

F: gagtcacacaggaaagtactagATGTTTTTAGCTCGTAATGCTGG

R: taactgcagCGGCCGCTACTAGTAATAAACGC


Both subparts were fused together by Overlap Extention PCR. All PCRs were performed with Phusion High Fidelity Polymerase using the standart protocol provided by the manufacturer. The final part was gel purified.The final part was gel purified and cloned in standart vector via restriction (EcoRI and PstI) and ligation.


Note: Uppercase characters in primer sequences correspond to regions that are complementary to the intended matrix. Lowercase characters mark regions of overlap for OEP and/or parts of biobrick regions with restriction sites for EcoRI and PstI.